HIV therapy

Two nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) plus either
One non-nucleoside RTI (NNRTI) OR One protease inhibitor

Nucleoside analog reverse transcriptase inhibitors (NARTIs, NRTIs)
S/E=Lactic acidosis

1.) Zidovudine (AZT, trade name Retrovir)
First HIV antiretroviral drug approved by the FDA

2.) Didanosine (ddI, trade name Videx)
Second FDA-approved antiretroviral drug
Analog of adenosine
PANCREATITIS

3.) Stavudin (d4T, trade names Zerit)

4.) Lamivudine (3TC, trade name Epivir)
Treatment of both HIV and hepatitis B

5.) Abacavir (ABC, trade name Ziagen)
Analog of guanosine

6.) Emtricitabine(FTC, trade name Emtriva [formerly Coviracil] )
Structurally similar to lamivudine
Approved for the treatment of HIV, undergoing clinical trials for hepatitis B


Non-nucleoside reverse transcriptase inhibitors NNRTIs
S/E=Stevens-Johnson syndrome

1.) Efavirenz (trade names Sustiva and Stocrin)

2.) Nevirapine (trade name Viramune)
S/E=liver failure

3.) Delavirdine(trade name Rescriptor)

4.) Etravirine (trade name Intelence)

Protease inhibitors

1.) Indinavir
S/E=Crystal induced nephropathy
2.) Abacavir
S/E=Hypersensitivity syndrome